Search results for " salivary glands biopsy"

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Is minor salivary gland biopsy more than a diagnostic tool in primary Sjorgren's syndrome? Association between clinical, histopathological, and molec…

2014

Objectives: Several histological scoring systems, including the focus score, performed in minor salivary glands (MSGs) by hematoxylin-eosin (H&E) staining, have been employed in clinical practice to assess the inflammatory infiltrate and provide the diagnosis of primary Sjorgren's syndrome (pSS). Aims of this study were to integrate different scoring systems and identify potential differences in the molecular profile of lymphoid cytokines related to germinal center (GC) formation and clinical subsets in pSS. Methods: Overall, 104 pSS patients and 40 subjects with sicca non-pSS were retrospectively evaluated. MSG biopsies were evaluated by H&E and immunofluorescence to assess histological pa…

MalePathologyT-LymphocytesBiopsyRetrospective Studiesalivary glands biopsyB-Lymphocytesmedicine.diagnostic_testbiologyLTαLTβMedicine (all)HypergammaglobulinemiaB-LymphocyteCXCL13CXCL12Middle AgedSjogren's syndrome salivary glands biopsySjogren's SyndromeCytokinesBAFFFemaleAntibodyHumanmusculoskeletal diseasesAdultmedicine.medical_specialtyBAFF; CCL19; CCL21; CCR7; CXCL12; CXCL13; CXCR4; CXCR5; Germinal center; LTα; LTβ; Minor salivary glands; Sjorgren's syndrome; Adult; B-Lymphocytes; Biomarkers; Biopsy; Cytokines; Female; Germinal Center; Humans; Male; Middle Aged; Retrospective Studies; Salivary Glands Minor; Sjogren's Syndrome; T-Lymphocytes; Rheumatology; Anesthesiology and Pain Medicine; Medicine (all)ImmunofluorescenceSalivary Glands MinorSalivary Glandstomatognathic systemRheumatologyInternal medicineBiopsyCCL19medicineHumansCXCL13B-cell activating factorCytokineRetrospective StudiesCXCR4Minor salivary glandbusiness.industryRetrospective cohort studyGerminal centerBiomarkermedicine.diseaseeye diseasesRheumatologyCXCR5Minorstomatognathic diseasesAnesthesiology and Pain MedicineT-LymphocyteSjorgren's syndromebiology.proteinbusinessBiomarkersCCL21CCR7
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